完整的测试系统,带有用于小完整肌肉的集成浴装置
温控浴板(尺寸从400μL到1900μL)
控制和测量力和长度
兼容标准和倒置显微镜
可以与Aurora Scientific 900B Sarcomere长度软件(HVSL / VSL)集成
分辨率低至0.01μN
力范围从0.5mN到1000mN
参考文献:
Norden, Diana M. et al. “Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function.” Brain, Behavior, and Immunity
Tangney, Jared R. et al. “Timing and magnitude of systolic stretch affect myofilament activation and mechanical work.” American Journal of Physiology-Heart and Circulatory Physiology
Gharanei, Mayel. “Investigation into the cardiotoxic effects of doxorubicin on contractile function and the protection afforded by cyclosporin A using the work-loop assay.” Toxicology in Vitro 28 (2014): 722-731.
Zuo, Li et al. “Low Po2 conditions induce reactive oxygen species formation during contractions in single skeletal muscle fibers.” American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
de Lange, Willem J. et al. “Ablation of cardiac myosin-binding protein-C accelerates contractile kinetics in engineered cardiac tissue.” Journal of General Physiology 141.1 (2013): 73-84.
Tangney, Jared R. “Effects of alterations in sarcomere structure and prestretch timing on cardiac muscle mechanics.” MSc Thesis. University of California San Diego (2012): 1-120.
Zuo, Li, Leonardo Nogueira, and Michael C. Hogan. “Reactive oxygen species formation during tetanic contractions in single isolated Xenopus myofibers.” Journal of Applied Physiology
Rhim, Caroline et al. “Effect of MicroRNA Modulation on Bioartificial Muscle Function.” Tissue Engineering: Part A 16.12 (2010): 3589-3597.