比利时Galapagos NV
Galapagos目标发现平台,提供新的出发点治疗药物和抗体,从而解决了业界的创新,疾病修饰药物的需要。Galapagos是为更好的药物利用这个平台的疾病领域有一个明确的需要。该公司的产品组合主要包括新的模式,对行动药物在骨关节疾病以及癌症的转移,恶病质和孤儿疾病的方案。为使方案的广泛产品组合的进展,建立了Galapagos在特定疾病领域的大型制药公司的风险共享合作关系。通过与MorphoSys的联盟,也正在开发中的Galapagos骨与关节疾病的抗体疗法。
Galapagos的服务部门,其中包括BioFocus和来自阿根最近收购的服务业务,提供了一个目标到药物发现的产品和服务的全部套件,制药,生物技术和病人的基础 - 包括目标和药物发现通过对前交货临床候选人。
Galapagos has developed a target discovery platform that provides novel starting points for drug and antibody therapies, thereby addressing the industry's need for innovative, disease-modifying medicines. Galapagos is exploiting this platform in disease areas for which there is a clear need for better medicines. The Company's product portfolio consists mainly of new mode-of-action drugs in bone and joint diseases as well as programs in cancer metastasis, cachexia and orphan diseases. To enable the progression of a broad portfolio of programs, Galapagos has established risk sharing alliances with big pharma companies in specific disease areas. Through an alliance with MorphoSys, Galapagos is also developing new antibody therapies in bone and joint diseases.
Galapagos' service division, which includes BioFocus and the recently acquired service operations from Argenta, offers a full suite of target-to-drug discovery products and services to pharma, biotech and patient foundations - encompassing target and drug discovery through to the delivery of pre-clinical candidates.
Galapagos was founded in 1999 as a joint venture between Crucell and Tibotec. From the start, Galapagos has operated a hybrid business model, combining internal discovery programs with service activities. In 2002 the Company raised €23.4 million in a private placement. In May 2005, the Company raised €22.4 million through an initial public offering on Euronext Brussels and Amsterdam (ticker symbol: GLPG). Galapagos raised an additional €60 million through private placements in 2006 and 2009 and a further €4.4 million through an equity investment by GlaxoSmithKline in 2007. Through a Level 1 ADR listing in the US, Galapagos is traded on the U.S. OTC market under the ticker symbol GLPYY.
R&D division
In December 2006 Galapagos acquired ProSkelia in Romainville, France, from ProStrakan via an all-share transaction. With ProSkelia, Galapagos obtained R&D operations and a product portfolio of products focused on musculoskeletal diseases (osteoporosis, cachexia and bone metastasis).
Galapagos has entered into long term alliances for the majority of its research programs with top ten pharma companies. These risk sharing alliances enable Galapagos to build a pipeline of more than 50 programs, based predominantly on proprietary targets that the Company has identified. Through this alliance strategy, Galapagos is eligible to receive approximately €3 billion in success-dependent milestone revenue plus up to double-digit royalties on commercial products.
Service division
In October 2005 Galapagos acquired BioFocus, a drug discovery company based in Saffron Walden, UK. In 2006, Galapagos acquired the drug discovery operations of Discovery Partners International and UK-based Inpharmatica Ltd. Galapagos acquired the structure-based drug discovery business of Sareum Holdings plc in 2008. These strategic acquisitions enable BioFocus to offer a full suite of target-to-candidate drug discovery products and services, encompassing target discovery and validation, screening and drug discovery through to delivery of pre-clinical candidates.
In February 2010, Galapagos acquired Argenta's service operations. Together, Argenta and BioFocus form one of the world's largest drug discovery service organizations, with 350 employees, an estimated €70 M in annual turnover and significant profitability.