美国Spiral Biotech, Inc. (SBI), 
Advanced仪器公司成立于1955年，总部设在麻萨诸塞州，它在冰点低压技术应用方面是世界主要权威。该公司是医学实验室和工业实验室所用诊断测试系统的主要供应商。Advanced集团公司由Advanced Instruments公司(冰点渗透压仪、冰点测定仪)、Fiske Associates公司(冰点渗透压仪)和Spiral Biotech公司(菌落记数仪)，其公司生产的冰点渗透压仪处于世界最领先的地位，他的冰点渗透压仪在美国的市场占有率在95%以上，在欧洲市场占有率超过70%，是唯一通过美国药典的最有权威的生产厂家。

Spiral Biotech, Inc. (SBI), an Advanced Instruments Company, produces automated microbiology systems for research, food, dairy, and environmental sciences laboratories.

Spiral Biotech first commercialized the technique of Spiral Plating in 1976. Since that time, the company has focused on automating the pre-analytical and analytical steps involved with traditional microbial enumeration. SBI products include colony counters, plating systems, anaerobic workstations, susceptibility test software, air samplers, and sample prep tools.

Spiral Biotech's newest colony counting system is the Color QCount®, with ColorCount™ color recognition software. The instrument is designed to work with the new chromogenic agars becoming popular for high-productivity colony counting that involves multiple strains of bacteria.