使用计算机控制的刺激量化机械敏感性

评估超阈值机械敏感性

测量机械阈值而不进行多次测试

范围：0.5N - 10N

卓越的分辨率（至0.3mN）

以任何方向运作

***小化轴外力

提供的提示范围（0.5,0.8,1,1.5,2,3毫米直径）

应用区域在整个力范围内保持不变

参考文献：

Kumar, Siddarth. et al. “Viscoelastic characterization of the primate finger pad in vivo by microstep indentation and three-dimensional finite element models for tactile sensation studies .” Journal of Biomechanical Engineering 137.6 (2015): 061002.

Qi, Huixin et al. “Cortical neuron response properties are related to lesion extent and behavioral recovery after sensory loss from spinal cord injury in monkeys.” The Journal of Neuroscience 34.12 (2014): 4345-4363.

Dieudonné, Alexandre et al. “Encoding properties of the mechanosensory neurons in the Johnston's organ of the hawk moth, Manduca sexta.” The Journal of Experimental Biology 217.17 (2014): 3045-3056.

Milenkovic, Nevena et al. “A somatosensory circuit for cooling perception in mice.” Nature Neuroscience17.11 (2014): 1560-1566.

Reed, Jamie L. et al. “Effects of spatiotemporal stimulus properties on spike timing correlations in owl monkey primary somatosensory cortex.” Journal of Neurophysiology 108.12 (2012): 3353-3369.

Jankowski, Michael P. et al. “Dynamic changes in heat transducing channel TRPV1 expression regulate mechanically insensitive, heat sensitive C-fiber recruitment after axotomy and regeneration.” The Journal of Neuroscience 32.49 (2012): 17869-17873.

Molliver, Derek C. et al. “The ADP receptor P2Y1 is necessary for normal thermal sensitivity in cutaneous polymodal nociceptors.” Molecular Pain 7.1 (2011): 13.

Ge, Weiqing, and Partap S. Khalsa. “Encoding of compressive stress during indentation by group III and IV muscle mechano-nociceptors in rat gracilis muscle.” Journal of Neurophysiology 89.2 (2003): 785-792.

Bove, Geoffrey M., Daniel R. Robichaud, and Peter Grigg. “Three-dimensional load analysis of indentation stimulators.” Journal of Neuroscience Methods 123.1 (2003): 23-30.

Khalsa, Partap S., Ce Zhang, and Yi-Xian Qin. “Encoding of location and intensity of noxious indentation into rat skin by spatial populations of cutaneous mechano-nociceptors.” Journal of Neurophysiology 83.5 (2000): 3049-3061.

300C-I机械刺激器是***种自动电子von Frey设备，具有在单个应用点测量和控制力和长度的附加功能。300C-I采用手持式von Frey灯丝或其他手持式机械刺激器来消除力量的变化和尴尬。我们的计算机控制机械刺激器消除了与von Frey细丝和其他电子von Frey系统相关的不可避免的手震颤。这消除了力应用中的相关变化。

Aurora Scientific的机械刺激器无需多次测试即可确定阈值，从而提高了吞吐量。力的施加和刺激的时间是***致和精确的，从而消除了与手持设备相关的可变性。

机械刺激器能够在预设的时间段内施加恒定的力，并具有以预定速率调节力的附加功能。刺激可以以长度或力的任何组合应用，并且可以遵循任意的力或距离施加曲线，因此施力不限于简单的力斜坡。

恒定和可重复力的传递确保实验，受试者和研究之间保持***致性，从而减少数据中可避免的错误并提高您的发现质量。